OBJECTIVE: This study aimed to determine the relationship between rs17576 (MMP-9) polymorphism and increased cancer risk in a Brazilian breast cancer cohort. METHODS: This study included 141 women (71 breast cancer patients and 70 controls without breast cancer) who donated 3 mL of their peripheral blood for genomic DNA extraction. This DNA was then genotyped using a real-time polymerase chain reaction. RESULTS: The AG (rs17576) genotype was identified in 26 (18.43%) participants in the case group and in 22 (15.60%) participants in the control group (p=0.274), while the GG genotype was identified in ten (7.09%) participants in the case group and in one (0.70%) participant in the control group (p<0.003 - OR (95% CI) 13.13 (1.73, 593.08). No significant difference in the incidence rates was observed for AG or GG rs17576 genotypes in premenopausal women, p=0.813 and p=0.556, respectively. However, in postmenopausal women, the AG genotype was shown to occur in 14 (22.5%) participants in the case group and in 4 (6.45%) participants in the control (p<0.043), while GG genotype occurred in eight (12.90%) of the individuals in the case group and in none of the individuals in the control group (p<0.006). CONCLUSION: In this study, the MMP-9 rs17576 GG polymorphic variant was shown to be significantly associated with breast cancer risk in premenopausal women, while the AG and GG genotypes were associated with increased cancer risk in postmenopausal women.

RESUMO Introdução: A desidratação é uma condição fisiológica que decorre de perda hídrica prolongada, com consequente elevação da temperatura corporal e redução do desempenho dos atletas. Objetivo: Avaliar o nível de conhecimento e o grau de hidratação de jogadores juniores de futebol. Métodos: Trata-se de um estudo transversal, envolvendo 14 jogadores de futebol, que foram avaliados quanto ao percentual de perda de peso após exercício (desidratação relativa), pH e densidade da urina e nível de conhecimento sobre hidratação. A análise estatística foi realizada por meio do software SPSS versão 18.0, utilizando um intervalo de confiança de 95%, com nível de significância com p < 0,05. Resultados: Pôde-se verificar que 92,85% dos jogadores apresentaram eutrofia e os valores médios de desidratação relativa, densidade urinária e pH foram de -0,89%, 1.034,43, e 5,64, respectivamente, com o que se revelou desidratação para as posições com maior desgaste físico e 48,9% dos jogadores apresentam conhecimento regular sobre hidratação. Conclusão: A desidratação encontrada em jogadores juniores pode ser influenciada por diferentes posições em campo e esquema tático do jogo.

ABSTRACT Introduction: Dehydration is a physiological condition that results from prolonged water loss, with consequent elevation of body temperature and reduced athletes’ performance. Objective: To evaluate the level of knowledge and the degree of hydration of junior soccer players. Methods: This is a cross-sectional study involving 14 soccer players who were evaluated for weight loss after exercise (relative dehydration), pH and density of urine and the level of knowledge about hydration. Statistical analysis was performed using SPSS software version 18.0, using a 95% confidence interval, with significance level of p<0.05. Results: It was possible to verify that 92.85% of the players were eutrophic and the mean values of relative dehydration, urinary density and pH were of -0.89%, 1,034.43, and 5.64, respectively, revealing dehydration for positions with greater physical wear and 48.9% of the players had a regular knowledge about hydration. Conclusion: The dehydration found in junior players can be influenced by different positions in the field and tactical scheme of the game.

RESUMEN Introducción: La deshidratación es una condición fisiológica que resulta de la pérdida prolongada de agua, con la consiguiente elevación de la temperatura corporal y la reducción de rendimiento de los atletas. Objetivo: Evaluar el nivel de conocimiento y el grado de hidratación de jugadores de fútbol juvenil. Métodos: Se trata de un estudio transversal que incluyó a 14 jugadores de fútbol, que fueron evaluados para el porcentaje de pérdida de peso después del ejercicio (deshidratación relativa), el pH y la densidad de la orina y el nivel de conocimiento sobre la hidratación. El análisis estadístico se realizó mediante el software SPSS versión 18.0 usando un intervalo de confianza de 95%, con un nivel de significación de p < 0,05. Resultados: Se verificó que 92,85% de los jugadores eran eutróficos y los valores promedio de deshidratación relativa, densidad y pH urinario fueron -0,89%, 1.034,43, y 5,64, respectivamente, que reveló deshidratación en las posiciones con mayor desgaste físico y que el 48,9% de los jugadores tiene un conocimiento normal sobre la hidratación. Conclusión: La deshidratación encontrada en jugadores juveniles puede ser influenciada por diferentes posiciones en el campo y el juego táctico.